Zoovet Travel · Practical Guides for International Pet Travel and Export February 2026
Practical guide — travel medicine and international export

How to prepare your dog for a long flight without him suffering

Dr. Jessica Camacho's technical guide on the physiological and metabolic preparation of dogs for long-haul international flights.

Jessica Ysabel Camacho Garcia, DVM — CMVP 12434 — Zoovet Travel, Trujillo, Peru  |  February 2026
How to prepare your dog for a long flight: physiological and metabolic preparation
Scope statement — required reading This article is a descriptive technical document. It is not legal or individualized veterinary advice. It does not replace official regulations of any jurisdiction nor the assessment of the responsible veterinarian.

Requirements vary by country, route, species and airline. Regulations change frequently. Verification with the competent health authority of the destination and transit country is mandatory before any export process.

Certificate issuance is the sole responsibility of the authorized veterinarian. This article does not override that professional judgment.

The success of a transatlantic transfer does not lie in the luck of ramp handling, but in the stability of the animal's hypothalamic-pituitary-adrenal axis weeks before takeoff. Understandhow to prepare your dog for a long flight without him sufferingIt involves managing the neuroendocrine response to stimuli that the dog cannot process naturally. In Trujillo, we frequently see owners who rely on last-minute sedatives, ignoring that chemical suppression of the central nervous system is the main cause of cardiorespiratory collapses at altitude.

Section 1Management of metabolic stress and the microbiota

A flight of more than eight hours subjects the body to a cascade of cortisol that immediately alters the permeability of the intestinal barrier. This response to acute chronic stress causes an imbalance in the microbiota, known as dysbiosis, which weakens the animal's immune system before facing the pathogens of the destination country. Technical preparation must include prior digestive stabilization to avoid osmotic diarrhea or vomiting induced by anxiety during transit.

Neuroendocrine integration defines whether the dog will enter a state of behavioral freezing or whether it will maintain its vital functions stable despite noise and vibrations. The scientific details about this phenomenon are set out in The gut-brain axis in dogs and cats during international transport: neuroendocrine integration, microbiota and energy metabolism. Implementing a specialized nutritional support protocol allows the brain to receive the appropriate signals to mitigate cellular panic during confinement in the pressurized warehouse.

Dog on long-haul international flight: pre-travel protocol

Section 2The sedation trap and the risk of hypoxia

Administration of acepromazine or benzodiazepines to "calm down" the dog on the plane overrides postural correction reflexes and depresses respiratory rate in an already oxygen-limited environment. The cargo holds maintain an altitude equivalent to 2,400 meters above sea level, where the partial pressure of oxygen is lower than that of Trujillo or Lima. A sedated animal loses the ability to react to mild hypoxia, resulting in hypoventilation that can be fatal without direct veterinary supervision.

Airlines prohibit the transportation of animals under the influence of psychotropic drugs due to the high rate of sudden death recorded in recent decades. The safe medical alternative is systematic desensitization to the carrier, getting the dog to identify the travel box as a low-reactivity refuge. This process takes time and cannot be replaced with a pill administered at the airport counter under the pressure of boarding time.

Section 3Chronobiology and the adjustment of the circadian cycle

The crossing of several time zones generates a circadian desynchronization that affects basal body temperature and melatonin secretion in the dog. This phenomenon, similar to human jet lag, alters periods of rest and wakefulness, causing the animal to arrive at its destination in a state of severe metabolic exhaustion. Adjusting feeding and light exposure routines days before departure makes it easier for the dog's biological clock to synchronize more quickly with the time of the country of arrival.

The lack of natural light in the cargo hold acts as a disruptor of biological rhythms, which intensifies post-flight fatigue and initial disorientation. In our practice, we prescribe light management protocols and specific intake times for each international journey, reducing the impact of time change on the patient's physiology. A dog that travels with its circadian cycle pre-adjusted shows a much faster recovery and presents fewer episodes of separation anxiety when settling into its new home.

Section 4Technical hydration against cabin dryness

The recycled air inside an airplane has extremely low humidity levels, which accelerates fluid loss through breathing and mucous membranes. A dehydrated dog has more viscous blood, which makes thermoregulation difficult and increases the workload of the heart during flight. Preparation includes ensuring optimal blood volume days before, but avoiding overhydration just before loading so as not to cause urinary emergencies that increase the animal's anxiety.

Drip drinkers are the only efficient tool to provide water during the ride without it spilling due to engine vibrations or turbulence. Instructing the dog in the use of these devices weeks before export ensures that the animal keeps its mucous membranes moist and its internal temperature under control. Dehydration is not just thirst; It is a risk factor for the development of acute kidney failure in older patients or with specific racial predispositions.

Section 5What should be resolved before starting

The choice of carrier should follow IATA LAR standards, allowing the dog to stand, turn and lie down without touching the walls. A small transport box restricts ventilation and causes an increase in temperature due to radiant heat, which can lead to heat stroke even in air-conditioned cabins. In Peru, many families purchase transporters based on price, without considering that one centimeter less in ceiling height is cause for immediate rejection by ramp personnel.

The final clinical checkup should include a thorough cardiovascular examination to rule out murmurs or arrhythmias that would be exacerbated by low oxygen pressure in flight. SENASA in Peru requires a health certificate issued by a registered veterinarian that guarantees that the animal is free of infectious diseases and in physical condition for travel. It is not an office procedure; It is a medical validation of the patient's integrity to survive the extreme conditions of long-distance international transportation.

Internal and external deworming must be carried out with broad-spectrum products that meet the requirements of the destination country within regulatory deadlines. Countries such as the United Kingdom or Norway require that treatment against the Echinococcus multilocularis parasite be applied between exactly 24 and 120 hours before entering the territory. An error in the treatment time window will invalidate the entire documentary file, causing the dog to be detained at the border or deported at the owner's expense.

A metabolic and behavioural preparation protocol allows the veterinarian to design a structured plan and minimise flight risks. Zoovet Travel designs physiological conditioning plans in Trujillo to ensure preparing your dog for a long flight is a clinical success.

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